It is uncommon for them to appear de novo later in childhood. They enlarge proportionately with the child's growth and darken with sun exposure. In patients with multiple cafe–au–lait spots it is important to obtain a family history of similar lesions or disorders known to be associated with cafe–au–lait macules.
Neurofibromatosis type 1 is a genetic condition that can cause a variety of symptoms, including: multiple flat, light-brown patches of skin pigment, called cafÃ©–au–lait macules or spots. skinfold freckling. visible neurofibromas that appear as bumps on or under the skin.
Most newborns that have the neurofibromatosis gene mutation show few or no signs. Cafe–au–lait spots are usually noticed in the first few weeks of life, or may appear earlier.. Occasionally, such plexiform neurofibromas are noticed in the newborn period, where they may appear as a soft swelling under the skin.
CafÃ© au lait spots, or cafÃ© au lait macules, are flat, pigmented birthmarks. The name cafÃ© au lait is French for "coffee with milk" and refers to their light-brown color .
NF1 is suspected when there are at least six cafÃ©–au–lait spots measuring at least 5 mm. Sometimes, neurofibromas occur within the skin and appear as a small. and become apparent because of pain or sudden growth of a neurofibroma.